Final project Essay Example | Topics and Well Written Essays - 1250 words

Final project - Essay ExampleThe main conditions found in comorbidity to MDD includes Obsessive Compulsive disorder,Post Traumatic Stress Disorder and the Panic Disorders. (Kessler,1996) Currently the treatment of MDD is centred around the selective serotonin reuptake receptor inhibitors (SSRI). This is based on the fact the main predilection elevator neurotransmitter of our body and found at synaptic junctions are actively reuptake so the availibilty of serotonin at the synapse decreases, trim the mood and causing depression. SSRIs inhibits this uptake by inhibiting the reuptake receptors of serotonin in the presynaptic regions found in the nucleus accumbens and ventral tegmentum area and hence causing mood elevations. Although antidepressant medications are often prescribed to people with MDD, it is estimated that 20-40% of depressed people do not benefit from taking medication ( Kirsch 2008,Hays,1995)).Apart from the efficacy these medications can also cause side effects like d rying of mouth, insomnia and others amongst the few. Thus, researchers are developing other possible ways to reduce depressive symptoms. One such depression treatment utility(a) to medication is the transcranial magnetic stimulation or TMS. Briefly, TMS treatment involves placing a coil on the scalp surface and passing a accepted by it (the get hold of details of the strength and rate of the current are beyond our purposes). When the current passes into neural tissue it affects the way the neurons operate, in a therapeutic way. Objective and train of the Study We wanted to analyze whether the TMS approach is effective in reduction of the episodes of depression from the baseline levels at the end of week 4 in the major depressive disorder patients. Methodology The study was conducted across multiple sites but the procedures were the same across locations. The sites involved were Florida, Oregon, and Washington. Across locations, participants with a history of antidepressant-res istant MDD were randomly assigned to each an active or a sham TMS condition. In the active condition, participants were actually given the TMS treatment. In the sham condition, participants were not given the TMS treatment but went through a similar procedure in each session (e.g., they came in for sessions in which a coil was placed on their heads but no current was lay out through it). So the sham condition was considered to be a type of placebo treatment. This was done to minimize the treatment limited bias of the study. The study was run duplicate-blind so that neither the participant nor the assistant running the session was aware of which condition the participant was in. Thus the experimental design of the study was a randomized, multicentric, placebo controlled double blind study. This design definitely was important to give the way for a powerful analysis. The MADRS haemorrhoid which is the set of scores that signifies the extent of depression of various parameters were canvass to give a final depression score. The convention is, more the MADRS scores more is the depression and vice versa. Thus the results were analyzed by comparing the MADRS scores at baseline and at 4 weeks after the TMS treatments were implemented to see the effect of that approach on MDD patients. Statistical analysis was carried out through SPSS computer software and paired sample t test was carried to find out the levels of significance. P values less than 0.05 were considered statistically significant. Results We analyzed findings on 4 questions to reach a conclusion. Q1.Ignoring the TMS condition and